3-Phytylmenadione
Category
3-Phytylmenadione Brand names, 3-Phytylmenadione Analogs
3-Phytylmenadione Brand Names Mixture
No information avaliable
3-Phytylmenadione Chemical_Formula
C31H46O2
3-Phytylmenadione RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
3-Phytylmenadione fda sheet
3-Phytylmenadione msds (material safety sheet)
3-Phytylmenadione Synthesis Reference
No information avaliable
3-Phytylmenadione Molecular Weight
450.696 g/mol
3-Phytylmenadione Melting Point
-20 oC
3-Phytylmenadione H2O Solubility
Insoluble in water
3-Phytylmenadione State
Liquid
3-Phytylmenadione LogP
8.841
3-Phytylmenadione Dosage Forms
Liquid
3-Phytylmenadione Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
3-Phytylmenadione Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
3-Phytylmenadione Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
3-Phytylmenadione Toxicity
No information avaliable
3-Phytylmenadione Patient Information
No information avaliable
3-Phytylmenadione Organisms Affected
Humans and other mammals
