IAB

Category

IAB




Useful info

IAB Brand names, IAB Analogs

IAB Brand Names Mixture

  • No information avaliable

    • IAB Chemical_Formula

    C47H73NO17

    IAB RX_link

    http://www.rxlist.com/cgi/generic2/amphoter.htm

    IAB fda sheet

    IAB FDA

    IAB msds (material safety sheet)

    IAB MSDS

    IAB Synthesis Reference

    No information avaliable

    IAB Molecular Weight

    924.079 g/mol

    IAB Melting Point

    170.0 oC

    IAB H2O Solubility

    750 mg/L

    IAB State

    Solid

    IAB LogP

    0.947

    IAB Dosage Forms

    Slow intravenous-infusion

    IAB Indication

    Used to treat potentially life threatening fungal infections.

    IAB Pharmacology

    Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

    IAB Absorption

    Bioavailability is 100% for intravenous infusion.

    IAB Toxicity

    Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

    IAB Patient Information

    No information avaliable

    IAB Organisms Affected

    Various Fungus Species