Fungizone_Intravenous
Category
Fungizone_Intravenous Brand names, Fungizone_Intravenous Analogs
Fungizone_Intravenous Brand Names Mixture
No information avaliable
Fungizone_Intravenous Chemical_Formula
C47H73NO17
Fungizone_Intravenous RX_link
http://www.rxlist.com/cgi/generic2/amphoter.htm
Fungizone_Intravenous fda sheet
Fungizone_Intravenous msds (material safety sheet)
Fungizone_Intravenous Synthesis Reference
No information avaliable
Fungizone_Intravenous Molecular Weight
924.079 g/mol
Fungizone_Intravenous Melting Point
170.0 oC
Fungizone_Intravenous H2O Solubility
750 mg/L
Fungizone_Intravenous State
Solid
Fungizone_Intravenous LogP
0.947
Fungizone_Intravenous Dosage Forms
Slow intravenous-infusion
Fungizone_Intravenous Indication
Used to treat potentially life threatening fungal infections.
Fungizone_Intravenous Pharmacology
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Fungizone_Intravenous Absorption
Bioavailability is 100% for intravenous infusion.
Fungizone_Intravenous Toxicity
Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
Fungizone_Intravenous Patient Information
No information avaliable
Fungizone_Intravenous Organisms Affected
Various Fungus Species
