Amphortericin_B
Category
Amphortericin_B Brand names, Amphortericin_B Analogs
Amphortericin_B Brand Names Mixture
No information avaliable
Amphortericin_B Chemical_Formula
C47H73NO17
Amphortericin_B RX_link
http://www.rxlist.com/cgi/generic2/amphoter.htm
Amphortericin_B fda sheet
Amphortericin_B msds (material safety sheet)
Amphortericin_B Synthesis Reference
No information avaliable
Amphortericin_B Molecular Weight
924.079 g/mol
Amphortericin_B Melting Point
170.0 oC
Amphortericin_B H2O Solubility
750 mg/L
Amphortericin_B State
Solid
Amphortericin_B LogP
0.947
Amphortericin_B Dosage Forms
Slow intravenous-infusion
Amphortericin_B Indication
Used to treat potentially life threatening fungal infections.
Amphortericin_B Pharmacology
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Amphortericin_B Absorption
Bioavailability is 100% for intravenous infusion.
Amphortericin_B Toxicity
Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
Amphortericin_B Patient Information
No information avaliable
Amphortericin_B Organisms Affected
Various Fungus Species
