HSDB_3008_IAB

Category

HSDB_3008_IAB




Useful info

HSDB_3008_IAB Brand names, HSDB_3008_IAB Analogs

HSDB_3008_IAB Brand Names Mixture

  • No information avaliable

    • HSDB_3008_IAB Chemical_Formula

    C47H73NO17

    HSDB_3008_IAB RX_link

    http://www.rxlist.com/cgi/generic2/amphoter.htm

    HSDB_3008_IAB fda sheet

    HSDB_3008_IAB FDA

    HSDB_3008_IAB msds (material safety sheet)

    HSDB_3008_IAB MSDS

    HSDB_3008_IAB Synthesis Reference

    No information avaliable

    HSDB_3008_IAB Molecular Weight

    924.079 g/mol

    HSDB_3008_IAB Melting Point

    170.0 oC

    HSDB_3008_IAB H2O Solubility

    750 mg/L

    HSDB_3008_IAB State

    Solid

    HSDB_3008_IAB LogP

    0.947

    HSDB_3008_IAB Dosage Forms

    Slow intravenous-infusion

    HSDB_3008_IAB Indication

    Used to treat potentially life threatening fungal infections.

    HSDB_3008_IAB Pharmacology

    Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

    HSDB_3008_IAB Absorption

    Bioavailability is 100% for intravenous infusion.

    HSDB_3008_IAB Toxicity

    Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

    HSDB_3008_IAB Patient Information

    No information avaliable

    HSDB_3008_IAB Organisms Affected

    Various Fungus Species