Amphotericin

Category

Amphotericin




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Amphotericin Brand names, Amphotericin Analogs

Amphotericin Brand Names Mixture

  • No information avaliable

    • Amphotericin Chemical_Formula

    C47H73NO17

    Amphotericin RX_link

    http://www.rxlist.com/cgi/generic2/amphoter.htm

    Amphotericin fda sheet

    Amphotericin FDA

    Amphotericin msds (material safety sheet)

    Amphotericin MSDS

    Amphotericin Synthesis Reference

    No information avaliable

    Amphotericin Molecular Weight

    924.079 g/mol

    Amphotericin Melting Point

    170.0 oC

    Amphotericin H2O Solubility

    750 mg/L

    Amphotericin State

    Solid

    Amphotericin LogP

    0.947

    Amphotericin Dosage Forms

    Slow intravenous-infusion

    Amphotericin Indication

    Used to treat potentially life threatening fungal infections.

    Amphotericin Pharmacology

    Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

    Amphotericin Absorption

    Bioavailability is 100% for intravenous infusion.

    Amphotericin Toxicity

    Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

    Amphotericin Patient Information

    No information avaliable

    Amphotericin Organisms Affected

    Various Fungus Species