Amphotericin
Category
Amphotericin Brand names, Amphotericin Analogs
Amphotericin Brand Names Mixture
Amphotericin Chemical_Formula
C47H73NO17
Amphotericin RX_link
http://www.rxlist.com/cgi/generic2/amphoter.htm
Amphotericin fda sheet
Amphotericin msds (material safety sheet)
Amphotericin Synthesis Reference
No information avaliable
Amphotericin Molecular Weight
924.079 g/mol
Amphotericin Melting Point
170.0 oC
Amphotericin H2O Solubility
750 mg/L
Amphotericin State
Solid
Amphotericin LogP
0.947
Amphotericin Dosage Forms
Slow intravenous-infusion
Amphotericin Indication
Used to treat potentially life threatening fungal infections.
Amphotericin Pharmacology
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Amphotericin Absorption
Bioavailability is 100% for intravenous infusion.
Amphotericin Toxicity
Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
Amphotericin Patient Information
No information avaliable
Amphotericin Organisms Affected
Various Fungus Species
