LNS-AmB

Category

LNS-AmB




Useful info

LNS-AmB Brand names, LNS-AmB Analogs

LNS-AmB Brand Names Mixture

  • No information avaliable

    • LNS-AmB Chemical_Formula

    C47H73NO17

    LNS-AmB RX_link

    http://www.rxlist.com/cgi/generic2/amphoter.htm

    LNS-AmB fda sheet

    LNS-AmB FDA

    LNS-AmB msds (material safety sheet)

    LNS-AmB MSDS

    LNS-AmB Synthesis Reference

    No information avaliable

    LNS-AmB Molecular Weight

    924.079 g/mol

    LNS-AmB Melting Point

    170.0 oC

    LNS-AmB H2O Solubility

    750 mg/L

    LNS-AmB State

    Solid

    LNS-AmB LogP

    0.947

    LNS-AmB Dosage Forms

    Slow intravenous-infusion

    LNS-AmB Indication

    Used to treat potentially life threatening fungal infections.

    LNS-AmB Pharmacology

    Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

    LNS-AmB Absorption

    Bioavailability is 100% for intravenous infusion.

    LNS-AmB Toxicity

    Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

    LNS-AmB Patient Information

    No information avaliable

    LNS-AmB Organisms Affected

    Various Fungus Species