AmBisome

Category

AmBisome




Useful info

AmBisome Brand names, AmBisome Analogs

AmBisome Brand Names Mixture

  • No information avaliable

    • AmBisome Chemical_Formula

    C47H73NO17

    AmBisome RX_link

    http://www.rxlist.com/cgi/generic2/amphoter.htm

    AmBisome fda sheet

    AmBisome FDA

    AmBisome msds (material safety sheet)

    AmBisome MSDS

    AmBisome Synthesis Reference

    No information avaliable

    AmBisome Molecular Weight

    924.079 g/mol

    AmBisome Melting Point

    170.0 oC

    AmBisome H2O Solubility

    750 mg/L

    AmBisome State

    Solid

    AmBisome LogP

    0.947

    AmBisome Dosage Forms

    Slow intravenous-infusion

    AmBisome Indication

    Used to treat potentially life threatening fungal infections.

    AmBisome Pharmacology

    Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

    AmBisome Absorption

    Bioavailability is 100% for intravenous infusion.

    AmBisome Toxicity

    Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

    AmBisome Patient Information

    No information avaliable

    AmBisome Organisms Affected

    Various Fungus Species