ABLC

ABLC Brand names, ABLC Analogs

ABLC Brand Names Mixture

No information avaliable

ABLC Chemical_Formula

C₄₇H₇₃NO₁₇

ABLC RX_link

http://www.rxlist.com/cgi/generic2/amphoter.htm

ABLC fda sheet

ABLC FDA

ABLC msds (material safety sheet)

ABLC MSDS

ABLC Synthesis Reference

No information avaliable

ABLC Molecular Weight

924.079 g/mol

ABLC Melting Point

170.0 ^oC

ABLC H₂O Solubility

750 mg/L

ABLC State

Solid

ABLC LogP

0.947

ABLC Dosage Forms

Slow intravenous-infusion

ABLC Indication

Used to treat potentially life threatening fungal infections.

ABLC Pharmacology

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

ABLC Absorption

Bioavailability is 100% for intravenous infusion.

ABLC side effects and Toxicity

Oral, rat: LD₅₀ = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

ABLC Patient Information