ABLC

Category

ABLC




Useful info

ABLC Brand names, ABLC Analogs

ABLC Brand Names Mixture

  • No information avaliable

    • ABLC Chemical_Formula

    C47H73NO17

    ABLC RX_link

    http://www.rxlist.com/cgi/generic2/amphoter.htm

    ABLC fda sheet

    ABLC FDA

    ABLC msds (material safety sheet)

    ABLC MSDS

    ABLC Synthesis Reference

    No information avaliable

    ABLC Molecular Weight

    924.079 g/mol

    ABLC Melting Point

    170.0 oC

    ABLC H2O Solubility

    750 mg/L

    ABLC State

    Solid

    ABLC LogP

    0.947

    ABLC Dosage Forms

    Slow intravenous-infusion

    ABLC Indication

    Used to treat potentially life threatening fungal infections.

    ABLC Pharmacology

    Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

    ABLC Absorption

    Bioavailability is 100% for intravenous infusion.

    ABLC Toxicity

    Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

    ABLC Patient Information

    No information avaliable

    ABLC Organisms Affected

    Various Fungus Species