Amphotericine_B
Category
Amphotericine_B Brand names, Amphotericine_B Analogs
Amphotericine_B Brand Names Mixture
No information avaliable
Amphotericine_B Chemical_Formula
C47H73NO17
Amphotericine_B RX_link
http://www.rxlist.com/cgi/generic2/amphoter.htm
Amphotericine_B fda sheet
Amphotericine_B msds (material safety sheet)
Amphotericine_B Synthesis Reference
No information avaliable
Amphotericine_B Molecular Weight
924.079 g/mol
Amphotericine_B Melting Point
170.0 oC
Amphotericine_B H2O Solubility
750 mg/L
Amphotericine_B State
Solid
Amphotericine_B LogP
0.947
Amphotericine_B Dosage Forms
Slow intravenous-infusion
Amphotericine_B Indication
Used to treat potentially life threatening fungal infections.
Amphotericine_B Pharmacology
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Amphotericine_B Absorption
Bioavailability is 100% for intravenous infusion.
Amphotericine_B Toxicity
Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
Amphotericine_B Patient Information
No information avaliable
Amphotericine_B Organisms Affected
Various Fungus Species
