Methylergonovine en es it fr

Methylergonovine Brand names, Methylergonovine Analogs

Methylergonovine Brand Names Mixture

  • No information avaliable

Methylergonovine Chemical_Formula


Methylergonovine RX_link

Methylergonovine fda sheet

Methylergonovine msds (material safety sheet)

Methylergonovine MSDS

Methylergonovine Synthesis Reference

A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)

Methylergonovine Molecular Weight

339.432 g/mol

Methylergonovine Melting Point

172 oC

Methylergonovine H2O Solubility

25 mg/mL

Methylergonovine State


Methylergonovine LogP


Methylergonovine Dosage Forms

Injection (intramuscular or intravenous); Tablet

Methylergonovine Indication

For the prevention and control of excessive bleeding following vaginal childbirth

Methylergonovine Pharmacology

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.

Methylergonovine Absorption

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Methylergonovine side effects and Toxicity

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Methylergonovine Patient Information

Methylergonovine Organisms Affected

Humans and other mammals