Methylergonovine
Methylergonovine Brand names, Methylergonovine Analogs
Methylergonovine Brand Names Mixture
- No information avaliable
Methylergonovine Chemical_Formula
C20H25N3O2
Methylergonovine RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Methylergonovine fda sheet
Methylergonovine msds (material safety sheet)
Methylergonovine Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Methylergonovine Molecular Weight
339.432 g/mol
Methylergonovine Melting Point
172 oC
Methylergonovine H2O Solubility
25 mg/mL
Methylergonovine State
Solid
Methylergonovine LogP
1.01
Methylergonovine Dosage Forms
Injection (intramuscular or intravenous); Tablet
Methylergonovine Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Methylergonovine Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Methylergonovine Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Methylergonovine side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Methylergonovine Patient Information
Methylergonovine Organisms Affected
Humans and other mammals
