Methylergobasin
Methylergobasin Brand names, Methylergobasin Analogs
Methylergobasin Brand Names Mixture
- No information avaliable
Methylergobasin Chemical_Formula
C20H25N3O2
Methylergobasin RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Methylergobasin fda sheet
Methylergobasin msds (material safety sheet)
Methylergobasin Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Methylergobasin Molecular Weight
339.432 g/mol
Methylergobasin Melting Point
172 oC
Methylergobasin H2O Solubility
25 mg/mL
Methylergobasin State
Solid
Methylergobasin LogP
1.01
Methylergobasin Dosage Forms
Injection (intramuscular or intravenous); Tablet
Methylergobasin Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Methylergobasin Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Methylergobasin Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Methylergobasin side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Methylergobasin Patient Information
Methylergobasin Organisms Affected
Humans and other mammals
