Methylergobasin en es it fr

Methylergobasin Brand names, Methylergobasin Analogs

Methylergobasin Brand Names Mixture

  • No information avaliable

Methylergobasin Chemical_Formula


Methylergobasin RX_link

Methylergobasin fda sheet

Methylergobasin msds (material safety sheet)

Methylergobasin MSDS

Methylergobasin Synthesis Reference

A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)

Methylergobasin Molecular Weight

339.432 g/mol

Methylergobasin Melting Point

172 oC

Methylergobasin H2O Solubility

25 mg/mL

Methylergobasin State


Methylergobasin LogP


Methylergobasin Dosage Forms

Injection (intramuscular or intravenous); Tablet

Methylergobasin Indication

For the prevention and control of excessive bleeding following vaginal childbirth

Methylergobasin Pharmacology

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.

Methylergobasin Absorption

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Methylergobasin side effects and Toxicity

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Methylergobasin Patient Information

Methylergobasin Organisms Affected

Humans and other mammals