Methergin
Methergin Brand names, Methergin Analogs
Methergin Brand Names Mixture
- No information avaliable
Methergin Chemical_Formula
C20H25N3O2
Methergin RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Methergin fda sheet
Methergin msds (material safety sheet)
Methergin Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Methergin Molecular Weight
339.432 g/mol
Methergin Melting Point
172 oC
Methergin H2O Solubility
25 mg/mL
Methergin State
Solid
Methergin LogP
1.01
Methergin Dosage Forms
Injection (intramuscular or intravenous); Tablet
Methergin Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Methergin Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Methergin Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Methergin side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Methergin Patient Information
Methergin Organisms Affected
Humans and other mammals
