Partergin en es it fr

Partergin Brand names, Partergin Analogs

Partergin Brand Names Mixture

  • No information avaliable

Partergin Chemical_Formula

C20H25N3O2

Partergin RX_link

http://www.rxlist.com/cgi/generic2/methylerg.htm

Partergin fda sheet

Partergin msds (material safety sheet)

Partergin MSDS

Partergin Synthesis Reference

A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)

Partergin Molecular Weight

339.432 g/mol

Partergin Melting Point

172 oC

Partergin H2O Solubility

25 mg/mL

Partergin State

Solid

Partergin LogP

1.01

Partergin Dosage Forms

Injection (intramuscular or intravenous); Tablet

Partergin Indication

For the prevention and control of excessive bleeding following vaginal childbirth

Partergin Pharmacology

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.

Partergin Absorption

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Partergin side effects and Toxicity

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Partergin Patient Information

Partergin Organisms Affected

Humans and other mammals