Methylergobrevin
Methylergobrevin Brand names, Methylergobrevin Analogs
Methylergobrevin Brand Names Mixture
- No information avaliable
Methylergobrevin Chemical_Formula
C20H25N3O2
Methylergobrevin RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Methylergobrevin fda sheet
Methylergobrevin msds (material safety sheet)
Methylergobrevin Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Methylergobrevin Molecular Weight
339.432 g/mol
Methylergobrevin Melting Point
172 oC
Methylergobrevin H2O Solubility
25 mg/mL
Methylergobrevin State
Solid
Methylergobrevin LogP
1.01
Methylergobrevin Dosage Forms
Injection (intramuscular or intravenous); Tablet
Methylergobrevin Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Methylergobrevin Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Methylergobrevin Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Methylergobrevin side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Methylergobrevin Patient Information
Methylergobrevin Organisms Affected
Humans and other mammals
