Methergine
Methergine Brand names, Methergine Analogs
Methergine Brand Names Mixture
- No information avaliable
Methergine Chemical_Formula
C20H25N3O2
Methergine RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Methergine fda sheet
Methergine msds (material safety sheet)
Methergine Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Methergine Molecular Weight
339.432 g/mol
Methergine Melting Point
172 oC
Methergine H2O Solubility
25 mg/mL
Methergine State
Solid
Methergine LogP
1.01
Methergine Dosage Forms
Injection (intramuscular or intravenous); Tablet
Methergine Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Methergine Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Methergine Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Methergine side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Methergine Patient Information
Methergine Organisms Affected
Humans and other mammals
