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Metenarin Brand names, Metenarin Analogs

Metenarin Brand Names Mixture

  • No information avaliable

Metenarin Chemical_Formula


Metenarin RX_link

Metenarin fda sheet

Metenarin msds (material safety sheet)

Metenarin MSDS

Metenarin Synthesis Reference

A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)

Metenarin Molecular Weight

339.432 g/mol

Metenarin Melting Point

172 oC

Metenarin H2O Solubility

25 mg/mL

Metenarin State


Metenarin LogP


Metenarin Dosage Forms

Injection (intramuscular or intravenous); Tablet

Metenarin Indication

For the prevention and control of excessive bleeding following vaginal childbirth

Metenarin Pharmacology

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.

Metenarin Absorption

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Metenarin side effects and Toxicity

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Metenarin Patient Information

Metenarin Organisms Affected

Humans and other mammals