Metenarin
Metenarin Brand names, Metenarin Analogs
Metenarin Brand Names Mixture
- No information avaliable
Metenarin Chemical_Formula
C20H25N3O2
Metenarin RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Metenarin fda sheet
Metenarin msds (material safety sheet)
Metenarin Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Metenarin Molecular Weight
339.432 g/mol
Metenarin Melting Point
172 oC
Metenarin H2O Solubility
25 mg/mL
Metenarin State
Solid
Metenarin LogP
1.01
Metenarin Dosage Forms
Injection (intramuscular or intravenous); Tablet
Metenarin Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Metenarin Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Metenarin Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Metenarin side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Metenarin Patient Information
Metenarin Organisms Affected
Humans and other mammals
