Methylergometrin
Methylergometrin Brand names, Methylergometrin Analogs
Methylergometrin Brand Names Mixture
- No information avaliable
Methylergometrin Chemical_Formula
C20H25N3O2
Methylergometrin RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Methylergometrin fda sheet
Methylergometrin msds (material safety sheet)
Methylergometrin Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Methylergometrin Molecular Weight
339.432 g/mol
Methylergometrin Melting Point
172 oC
Methylergometrin H2O Solubility
25 mg/mL
Methylergometrin State
Solid
Methylergometrin LogP
1.01
Methylergometrin Dosage Forms
Injection (intramuscular or intravenous); Tablet
Methylergometrin Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Methylergometrin Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Methylergometrin Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Methylergometrin side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Methylergometrin Patient Information
Methylergometrin Organisms Affected
Humans and other mammals
