Methylergonovin
Methylergonovin Brand names, Methylergonovin Analogs
Methylergonovin Brand Names Mixture
- No information avaliable
Methylergonovin Chemical_Formula
C20H25N3O2
Methylergonovin RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Methylergonovin fda sheet
Methylergonovin msds (material safety sheet)
Methylergonovin Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Methylergonovin Molecular Weight
339.432 g/mol
Methylergonovin Melting Point
172 oC
Methylergonovin H2O Solubility
25 mg/mL
Methylergonovin State
Solid
Methylergonovin LogP
1.01
Methylergonovin Dosage Forms
Injection (intramuscular or intravenous); Tablet
Methylergonovin Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Methylergonovin Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Methylergonovin Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Methylergonovin side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Methylergonovin Patient Information
Methylergonovin Organisms Affected
Humans and other mammals
