Methylergonovin en es it fr

Methylergonovin Brand names, Methylergonovin Analogs

Methylergonovin Brand Names Mixture

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Methylergonovin Chemical_Formula


Methylergonovin RX_link

Methylergonovin fda sheet

Methylergonovin msds (material safety sheet)

Methylergonovin MSDS

Methylergonovin Synthesis Reference

A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)

Methylergonovin Molecular Weight

339.432 g/mol

Methylergonovin Melting Point

172 oC

Methylergonovin H2O Solubility

25 mg/mL

Methylergonovin State


Methylergonovin LogP


Methylergonovin Dosage Forms

Injection (intramuscular or intravenous); Tablet

Methylergonovin Indication

For the prevention and control of excessive bleeding following vaginal childbirth

Methylergonovin Pharmacology

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.

Methylergonovin Absorption

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Methylergonovin side effects and Toxicity

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Methylergonovin Patient Information

Methylergonovin Organisms Affected

Humans and other mammals