Spametrin-M
Spametrin-M Brand names, Spametrin-M Analogs
Spametrin-M Brand Names Mixture
- No information avaliable
Spametrin-M Chemical_Formula
C20H25N3O2
Spametrin-M RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Spametrin-M fda sheet
Spametrin-M msds (material safety sheet)
Spametrin-M Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Spametrin-M Molecular Weight
339.432 g/mol
Spametrin-M Melting Point
172 oC
Spametrin-M H2O Solubility
25 mg/mL
Spametrin-M State
Solid
Spametrin-M LogP
1.01
Spametrin-M Dosage Forms
Injection (intramuscular or intravenous); Tablet
Spametrin-M Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Spametrin-M Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Spametrin-M Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Spametrin-M side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Spametrin-M Patient Information
Spametrin-M Organisms Affected
Humans and other mammals
