Methergen
Methergen Brand names, Methergen Analogs
Methergen Brand Names Mixture
- No information avaliable
Methergen Chemical_Formula
C20H25N3O2
Methergen RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Methergen fda sheet
Methergen msds (material safety sheet)
Methergen Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Methergen Molecular Weight
339.432 g/mol
Methergen Melting Point
172 oC
Methergen H2O Solubility
25 mg/mL
Methergen State
Solid
Methergen LogP
1.01
Methergen Dosage Forms
Injection (intramuscular or intravenous); Tablet
Methergen Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Methergen Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Methergen Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Methergen side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Methergen Patient Information
Methergen Organisms Affected
Humans and other mammals
