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Methergen Brand names, Methergen Analogs

Methergen Brand Names Mixture

  • No information avaliable

Methergen Chemical_Formula


Methergen RX_link

Methergen fda sheet

Methergen msds (material safety sheet)

Methergen MSDS

Methergen Synthesis Reference

A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)

Methergen Molecular Weight

339.432 g/mol

Methergen Melting Point

172 oC

Methergen H2O Solubility

25 mg/mL

Methergen State


Methergen LogP


Methergen Dosage Forms

Injection (intramuscular or intravenous); Tablet

Methergen Indication

For the prevention and control of excessive bleeding following vaginal childbirth

Methergen Pharmacology

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.

Methergen Absorption

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Methergen side effects and Toxicity

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Methergen Patient Information

Methergen Organisms Affected

Humans and other mammals