Methylergometrine
Methylergometrine Brand names, Methylergometrine Analogs
Methylergometrine Brand Names Mixture
- No information avaliable
Methylergometrine Chemical_Formula
C20H25N3O2
Methylergometrine RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Methylergometrine fda sheet
Methylergometrine msds (material safety sheet)
Methylergometrine Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Methylergometrine Molecular Weight
339.432 g/mol
Methylergometrine Melting Point
172 oC
Methylergometrine H2O Solubility
25 mg/mL
Methylergometrine State
Solid
Methylergometrine LogP
1.01
Methylergometrine Dosage Forms
Injection (intramuscular or intravenous); Tablet
Methylergometrine Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Methylergometrine Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Methylergometrine Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Methylergometrine side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Methylergometrine Patient Information
Methylergometrine Organisms Affected
Humans and other mammals
