Norforms
Norforms Brand names, Norforms Analogs
Norforms Brand Names Mixture
- No information avaliable
Norforms Chemical_Formula
C20H25N3O2
Norforms RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Norforms fda sheet
Norforms msds (material safety sheet)
Norforms Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Norforms Molecular Weight
339.432 g/mol
Norforms Melting Point
172 oC
Norforms H2O Solubility
25 mg/mL
Norforms State
Solid
Norforms LogP
1.01
Norforms Dosage Forms
Injection (intramuscular or intravenous); Tablet
Norforms Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Norforms Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Norforms Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Norforms side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Norforms Patient Information
Norforms Organisms Affected
Humans and other mammals
