Methylergobasine en es it fr

Methylergobasine Brand names, Methylergobasine Analogs

Methylergobasine Brand Names Mixture

  • No information avaliable

Methylergobasine Chemical_Formula


Methylergobasine RX_link

Methylergobasine fda sheet

Methylergobasine msds (material safety sheet)

Methylergobasine MSDS

Methylergobasine Synthesis Reference

A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)

Methylergobasine Molecular Weight

339.432 g/mol

Methylergobasine Melting Point

172 oC

Methylergobasine H2O Solubility

25 mg/mL

Methylergobasine State


Methylergobasine LogP


Methylergobasine Dosage Forms

Injection (intramuscular or intravenous); Tablet

Methylergobasine Indication

For the prevention and control of excessive bleeding following vaginal childbirth

Methylergobasine Pharmacology

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.

Methylergobasine Absorption

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Methylergobasine side effects and Toxicity

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Methylergobasine Patient Information

Methylergobasine Organisms Affected

Humans and other mammals