Methylergobasine
Methylergobasine Brand names, Methylergobasine Analogs
Methylergobasine Brand Names Mixture
- No information avaliable
Methylergobasine Chemical_Formula
C20H25N3O2
Methylergobasine RX_link
http://www.rxlist.com/cgi/generic2/methylerg.htm
Methylergobasine fda sheet
Methylergobasine msds (material safety sheet)
Methylergobasine Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Methylergobasine Molecular Weight
339.432 g/mol
Methylergobasine Melting Point
172 oC
Methylergobasine H2O Solubility
25 mg/mL
Methylergobasine State
Solid
Methylergobasine LogP
1.01
Methylergobasine Dosage Forms
Injection (intramuscular or intravenous); Tablet
Methylergobasine Indication
For the prevention and control of excessive bleeding following vaginal childbirth
Methylergobasine Pharmacology
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Methylergobasine Absorption
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Methylergobasine side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Methylergobasine Patient Information
Methylergobasine Organisms Affected
Humans and other mammals
