Flavoxate
Brand names,
Flavoxate
Analogs
Flavoxate
Brand Names Mixture
Flavoxate
Chemical_Formula
C24H25NO4
Flavoxate
RX_link
http://www.rxlist.com/cgi/generic3/flavoxate.htm
Flavoxate
fda sheet
Flavoxate
msds (material safety sheet)
Flavoxate
Synthesis Reference
No information avaliable
Flavoxate
Molecular Weight
391.46 g/mol
Flavoxate
Melting Point
No information avaliable
Flavoxate
H2O Solubility
10 mg/L
Flavoxate
State
Solid
Flavoxate
LogP
4.636
Flavoxate
Dosage Forms
Tablets (100 mg)
Flavoxate
Indication
For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.
Flavoxate
Pharmacology
Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several major cholin-ergically mediated functions, including contractions of urinary bladder smooth muscle and stimulation of salivary secretion.
Flavoxate
Absorption
Well absorbed from gastrointestinal tract.
Flavoxate
side effects and Toxicity
The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion.
Flavoxate
Patient Information
Flavoxate
Organisms Affected
Humans and other mammals