HEDP
Brand names,
HEDP
Analogs
HEDP
Brand Names Mixture
HEDP
Chemical_Formula
C24H25NO4
HEDP
RX_link
http://www.rxlist.com/cgi/generic3/flavoxate.htm
HEDP
fda sheet
HEDP
msds (material safety sheet)
HEDP
Synthesis Reference
No information avaliable
HEDP
Molecular Weight
391.46 g/mol
HEDP
Melting Point
No information avaliable
HEDP
H2O Solubility
10 mg/L
HEDP
State
Solid
HEDP
LogP
4.636
HEDP
Dosage Forms
Tablets (100 mg)
HEDP
Indication
For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.
HEDP
Pharmacology
Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several major cholin-ergically mediated functions, including contractions of urinary bladder smooth muscle and stimulation of salivary secretion.
HEDP
Absorption
Well absorbed from gastrointestinal tract.
HEDP
side effects and Toxicity
The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion.
HEDP
Patient Information
HEDP
Organisms Affected
Humans and other mammals