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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C24H25NO4
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RX_link
http://www.rxlist.com/cgi/generic3/flavoxate.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
391.46 g/mol
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Melting Point
No information avaliable
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H2O Solubility
10 mg/L
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State
Solid
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LogP
4.636
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Dosage Forms
Tablets (100 mg)
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Indication
For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.
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Pharmacology
Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several major cholin-ergically mediated functions, including contractions of urinary bladder smooth muscle and stimulation of salivary secretion.
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Absorption
Well absorbed from gastrointestinal tract.
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side effects and Toxicity
The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion.
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Patient Information
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Organisms Affected
Humans and other mammals