EHDP
Brand names,
EHDP
Analogs
EHDP
Brand Names Mixture
EHDP
Chemical_Formula
C24H25NO4
EHDP
RX_link
http://www.rxlist.com/cgi/generic3/flavoxate.htm
EHDP
fda sheet
EHDP
msds (material safety sheet)
EHDP
Synthesis Reference
No information avaliable
EHDP
Molecular Weight
391.46 g/mol
EHDP
Melting Point
No information avaliable
EHDP
H2O Solubility
10 mg/L
EHDP
State
Solid
EHDP
LogP
4.636
EHDP
Dosage Forms
Tablets (100 mg)
EHDP
Indication
For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.
EHDP
Pharmacology
Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several major cholin-ergically mediated functions, including contractions of urinary bladder smooth muscle and stimulation of salivary secretion.
EHDP
Absorption
Well absorbed from gastrointestinal tract.
EHDP
side effects and Toxicity
The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion.
EHDP
Patient Information
EHDP
Organisms Affected
Humans and other mammals