Hydroxyethanediphosphonic acid
Brand names,
Hydroxyethanediphosphonic acid
Analogs
Hydroxyethanediphosphonic acid
Brand Names Mixture
Hydroxyethanediphosphonic acid
Chemical_Formula
C24H25NO4
Hydroxyethanediphosphonic acid
RX_link
http://www.rxlist.com/cgi/generic3/flavoxate.htm
Hydroxyethanediphosphonic acid
fda sheet
Hydroxyethanediphosphonic acid
msds (material safety sheet)
Hydroxyethanediphosphonic acid
Synthesis Reference
No information avaliable
Hydroxyethanediphosphonic acid
Molecular Weight
391.46 g/mol
Hydroxyethanediphosphonic acid
Melting Point
No information avaliable
Hydroxyethanediphosphonic acid
H2O Solubility
10 mg/L
Hydroxyethanediphosphonic acid
State
Solid
Hydroxyethanediphosphonic acid
LogP
4.636
Hydroxyethanediphosphonic acid
Dosage Forms
Tablets (100 mg)
Hydroxyethanediphosphonic acid
Indication
For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.
Hydroxyethanediphosphonic acid
Pharmacology
Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several major cholin-ergically mediated functions, including contractions of urinary bladder smooth muscle and stimulation of salivary secretion.
Hydroxyethanediphosphonic acid
Absorption
Well absorbed from gastrointestinal tract.
Hydroxyethanediphosphonic acid
side effects and Toxicity
The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion.
Hydroxyethanediphosphonic acid
Patient Information
Hydroxyethanediphosphonic acid
Organisms Affected
Humans and other mammals