Acide etidronique [INN-French]
Brand names,
Acide etidronique [INN-French]
Analogs
Acide etidronique [INN-French]
Brand Names Mixture
Acide etidronique [INN-French]
Chemical_Formula
C24H25NO4
Acide etidronique [INN-French]
RX_link
http://www.rxlist.com/cgi/generic3/flavoxate.htm
Acide etidronique [INN-French]
fda sheet
Acide etidronique [INN-French]
msds (material safety sheet)
Acide etidronique [INN-French]
Synthesis Reference
No information avaliable
Acide etidronique [INN-French]
Molecular Weight
391.46 g/mol
Acide etidronique [INN-French]
Melting Point
No information avaliable
Acide etidronique [INN-French]
H2O Solubility
10 mg/L
Acide etidronique [INN-French]
State
Solid
Acide etidronique [INN-French]
LogP
4.636
Acide etidronique [INN-French]
Dosage Forms
Tablets (100 mg)
Acide etidronique [INN-French]
Indication
For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.
Acide etidronique [INN-French]
Pharmacology
Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several major cholin-ergically mediated functions, including contractions of urinary bladder smooth muscle and stimulation of salivary secretion.
Acide etidronique [INN-French]
Absorption
Well absorbed from gastrointestinal tract.
Acide etidronique [INN-French]
side effects and Toxicity
The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion.
Acide etidronique [INN-French]
Patient Information
Acide etidronique [INN-French]
Organisms Affected
Humans and other mammals