Didronel
Brand names,
Didronel
Analogs
Didronel
Brand Names Mixture
Didronel
Chemical_Formula
C24H25NO4
Didronel
RX_link
http://www.rxlist.com/cgi/generic3/flavoxate.htm
Didronel
fda sheet
Didronel
msds (material safety sheet)
Didronel
Synthesis Reference
No information avaliable
Didronel
Molecular Weight
391.46 g/mol
Didronel
Melting Point
No information avaliable
Didronel
H2O Solubility
10 mg/L
Didronel
State
Solid
Didronel
LogP
4.636
Didronel
Dosage Forms
Tablets (100 mg)
Didronel
Indication
For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.
Didronel
Pharmacology
Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several major cholin-ergically mediated functions, including contractions of urinary bladder smooth muscle and stimulation of salivary secretion.
Didronel
Absorption
Well absorbed from gastrointestinal tract.
Didronel
side effects and Toxicity
The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion.
Didronel
Patient Information
Didronel
Organisms Affected
Humans and other mammals