Dequest 2010
Brand names,
Dequest 2010
Analogs
Dequest 2010
Brand Names Mixture
Dequest 2010
Chemical_Formula
C24H25NO4
Dequest 2010
RX_link
http://www.rxlist.com/cgi/generic3/flavoxate.htm
Dequest 2010
fda sheet
Dequest 2010
msds (material safety sheet)
Dequest 2010
Synthesis Reference
No information avaliable
Dequest 2010
Molecular Weight
391.46 g/mol
Dequest 2010
Melting Point
No information avaliable
Dequest 2010
H2O Solubility
10 mg/L
Dequest 2010
State
Solid
Dequest 2010
LogP
4.636
Dequest 2010
Dosage Forms
Tablets (100 mg)
Dequest 2010
Indication
For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.
Dequest 2010
Pharmacology
Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several major cholin-ergically mediated functions, including contractions of urinary bladder smooth muscle and stimulation of salivary secretion.
Dequest 2010
Absorption
Well absorbed from gastrointestinal tract.
Dequest 2010
side effects and Toxicity
The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion.
Dequest 2010
Patient Information
Dequest 2010
Organisms Affected
Humans and other mammals