Dequest 2015
Brand names,
Dequest 2015
Analogs
Dequest 2015
Brand Names Mixture
Dequest 2015
Chemical_Formula
C24H25NO4
Dequest 2015
RX_link
http://www.rxlist.com/cgi/generic3/flavoxate.htm
Dequest 2015
fda sheet
Dequest 2015
msds (material safety sheet)
Dequest 2015
Synthesis Reference
No information avaliable
Dequest 2015
Molecular Weight
391.46 g/mol
Dequest 2015
Melting Point
No information avaliable
Dequest 2015
H2O Solubility
10 mg/L
Dequest 2015
State
Solid
Dequest 2015
LogP
4.636
Dequest 2015
Dosage Forms
Tablets (100 mg)
Dequest 2015
Indication
For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.
Dequest 2015
Pharmacology
Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several major cholin-ergically mediated functions, including contractions of urinary bladder smooth muscle and stimulation of salivary secretion.
Dequest 2015
Absorption
Well absorbed from gastrointestinal tract.
Dequest 2015
side effects and Toxicity
The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion.
Dequest 2015
Patient Information
Dequest 2015
Organisms Affected
Humans and other mammals