Dicumarine
Brand names,
Dicumarine
Analogs
Dicumarine
Brand Names Mixture
Dicumarine
Chemical_Formula
C19H12O6
Dicumarine
RX_link
No information avaliable
Dicumarine
fda sheet
Dicumarine
msds (material safety sheet)
Dicumarine
Synthesis Reference
Bikova N., et al. Farmatsiia (Sofia). 1954 Jan-Feb;4(1):23-6.
Dicumarine
Molecular Weight
336.295 g/mol
Dicumarine
Melting Point
290 oC
Dicumarine
H2O Solubility
128 mg/L
Dicumarine
State
Solid
Dicumarine
LogP
3.447
Dicumarine
Dosage Forms
No information avaliable
Dicumarine
Indication
For decreasing blood clotting
Dicumarine
Pharmacology
Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). It is also used in biochemical experiments as an inhibitor of reductases.
Dicumarine
Absorption
No information avaliable
Dicumarine
side effects and Toxicity
LD50=233 mg/kg (orally in mice); LD50=250 mg/kg (orally in rats)
Dicumarine
Patient Information
No information avaliable
Dicumarine
Organisms Affected
Humans and other mammals