Categoria
Extrinsic Factor
Marchi,
Extrinsic Factor
Analoghi
Extrinsic Factor
Marchi miscela
Liver-Stomach Concentrate with Intrinsic Factor (Special Liver-Stomach Concentrate + Vitamin B 12 + Iron + Ascorbic Acid + Folic Acid)
Extrinsic Factor
Formula chimica
C63H88CoN14O14P
Extrinsic Factor
RX link
http://www.rxlist.com/cgi/generic2/hminfr.htm
Extrinsic Factor
FDA foglio
Extrinsic Factor
DMS (foglio di materiale di sicurezza)
Extrinsic Factor
Sintesi di riferimento
Nessuna informazione disponibile
Extrinsic Factor
Peso molecolare
1355.37 g/mol
Extrinsic Factor
Temperatura di fusione
> 300 oC
Extrinsic Factor
H2O Solubilita
1.25E 004 mg / L
Extrinsic Factor
Stato
Solid
Extrinsic Factor
LogP
3.57
Extrinsic Factor
Forme di dosaggio
Intra-nasale gel; parenterale (orale)
Extrinsic Factor
Indicazione
Per il trattamento di anemia perniciosa (a causa della mancanza o l'inibizione del fattore intrinseco) e per la prevenzione e il trattamento di carenza di vitamina B 12.
Extrinsic Factor
Farmacologia
La vitamina B12 è un composto idrosolubile organometallici con uno ione cobalto trivalente legato all'interno di un anello Corrin. E isneeded per le cellule nervose e dei globuli rossi, e per rendere il DNA. La vitamina B12 è la causa di diverse forme di anemia.
Extrinsic Factor
Assorbimento
Prontamente assorbito nella metà inferiore dell'ileo.
Extrinsic Factor
Tossicita
Reazione anafilattica (rash cutaneo, prurito, dispnea)-dopo somministrazione parenterale. ORL-MUS LD50> 8000 mg / kg
Extrinsic Factor
Informazioni paziente
Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration. A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.
Extrinsic Factor
Atto interessato organismi
Gli esseri umani e altri mammiferi