Rubesol
Brand names,
Rubesol
Analogs
Rubesol
Brand Names Mixture
- Liver-Stomach Concentrate with Intrinsic Factor (Special Liver-Stomach Concentrate + Vitamin B 12 + Iron + Ascorbic Acid + Folic Acid)
Rubesol
Chemical_Formula
C63H88CoN14O14P
Rubesol
RX_link
http://www.rxlist.com/cgi/generic2/hminfr.htm
Rubesol
fda sheet
Rubesol
msds (material safety sheet)
Rubesol
Synthesis Reference
No information avaliable
Rubesol
Molecular Weight
1355.37 g/mol
Rubesol
Melting Point
> 300 oC
Rubesol
H2O Solubility
1.25E+004 mg/L
Rubesol
State
Solid
Rubesol
LogP
3.57
Rubesol
Dosage Forms
Intra-nasal gel; Parenteral (oral)
Rubesol
Indication
For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.
Rubesol
Pharmacology
Vitamin B12 is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It isneeded for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia.
Rubesol
Absorption
Readily absorbed in the lower half of the ileum.
Rubesol
side effects and Toxicity
Anaphylactic reaction (skin rash, itching, wheezing)-after parenteral administration. ORL-MUS LD50 > 8000 mg/kg
Rubesol
Patient Information
Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration. A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.
Rubesol
Organisms Affected
Humans and other mammals