Cyanocobalamin Vitamin B12
Brand names,
Cyanocobalamin Vitamin B12
Analogs
Cyanocobalamin Vitamin B12
Brand Names Mixture
- Liver-Stomach Concentrate with Intrinsic Factor (Special Liver-Stomach Concentrate + Vitamin B 12 + Iron + Ascorbic Acid + Folic Acid)
Cyanocobalamin Vitamin B12
Chemical_Formula
C63H88CoN14O14P
Cyanocobalamin Vitamin B12
RX_link
http://www.rxlist.com/cgi/generic2/hminfr.htm
Cyanocobalamin Vitamin B12
fda sheet
Cyanocobalamin Vitamin B12
msds (material safety sheet)
Cyanocobalamin Vitamin B12
Synthesis Reference
No information avaliable
Cyanocobalamin Vitamin B12
Molecular Weight
1355.37 g/mol
Cyanocobalamin Vitamin B12
Melting Point
> 300 oC
Cyanocobalamin Vitamin B12
H2O Solubility
1.25E+004 mg/L
Cyanocobalamin Vitamin B12
State
Solid
Cyanocobalamin Vitamin B12
LogP
3.57
Cyanocobalamin Vitamin B12
Dosage Forms
Intra-nasal gel; Parenteral (oral)
Cyanocobalamin Vitamin B12
Indication
For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.
Cyanocobalamin Vitamin B12
Pharmacology
Vitamin B12 is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It isneeded for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia.
Cyanocobalamin Vitamin B12
Absorption
Readily absorbed in the lower half of the ileum.
Cyanocobalamin Vitamin B12
side effects and Toxicity
Anaphylactic reaction (skin rash, itching, wheezing)-after parenteral administration. ORL-MUS LD50 > 8000 mg/kg
Cyanocobalamin Vitamin B12
Patient Information
Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration. A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.
Cyanocobalamin Vitamin B12
Organisms Affected
Humans and other mammals