Docigram
Brand names,
Docigram
Analogs
Docigram
Brand Names Mixture
- Liver-Stomach Concentrate with Intrinsic Factor (Special Liver-Stomach Concentrate + Vitamin B 12 + Iron + Ascorbic Acid + Folic Acid)
Docigram
Chemical_Formula
C63H88CoN14O14P
Docigram
RX_link
http://www.rxlist.com/cgi/generic2/hminfr.htm
Docigram
fda sheet
Docigram
msds (material safety sheet)
Docigram
Synthesis Reference
No information avaliable
Docigram
Molecular Weight
1355.37 g/mol
Docigram
Melting Point
> 300 oC
Docigram
H2O Solubility
1.25E+004 mg/L
Docigram
State
Solid
Docigram
LogP
3.57
Docigram
Dosage Forms
Intra-nasal gel; Parenteral (oral)
Docigram
Indication
For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.
Docigram
Pharmacology
Vitamin B12 is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It isneeded for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia.
Docigram
Absorption
Readily absorbed in the lower half of the ileum.
Docigram
side effects and Toxicity
Anaphylactic reaction (skin rash, itching, wheezing)-after parenteral administration. ORL-MUS LD50 > 8000 mg/kg
Docigram
Patient Information
Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration. A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.
Docigram
Organisms Affected
Humans and other mammals