Cobione
Cobione Brand names, Cobione Analogs
- Anacobin
- B-Twelve
- B-Twelve Ora
- Berubigen
- Betalin 12, Crystalline
- Betalin-12
- Betaline-12
- Betolvex
- Bevatine-12
- Bevidox
- Bevidox Concentrate
- Biocobalamine
- Byladoce
- CN-B12
- Cabadon M
- Cobadoce Forte
- Cobalamin
- Cobalamin Concentrate
- Cobalamin, Cyanide
- Cobalamin, Cyano-
- Cobalin
- Cobamin
- Cobavite
- Cobione
- Coobalamed
- Copharvit 5000
- Cosmo-Rey
- Cotel
- Covit
- Crystamin
- Crystamine
- Crystimin
- Crystwel
- Cyano-B12
- Cyanobalamin Concentrate
- Cyanocobalamin Vitamin B12
- Cyanocobalamine
- Cyanocobalmin
- Cycobemin
- Cycolamin
- Cykobemin
- Cykobeminet
- Cynobal
- Cyomin
- Cyredin
- Cytacon
- Cytamen
- Cytobion
- Depinar
- Dicopac
- Dimethylbenzimidazoylcobamide
- Distivit
- Dobetin
- Docemine
- Docibin
- Docigram
- Docivit
- Dodecabee
- Dodecavite
- Dodex
- Ducobee
- Duodecibin
- Embiol
- Emociclina
- Eritrone
- Erycytol
- Erythrotin
- Euhaemon
- Extrinsic Factor
- Factor II
- Fermin
- Fresmin
- Hemomin
- Hepagon
- Hepavis
- Hepcovite
- Hylugel Plus
- Lactobacillus Lactis Dorner Factor
- Lld Factor
- Macrabin
- Megabion
- Megalovel
- Milbedoce
- Millevit
- Nagravon
- Normocytin
- Novidroxin
- Pernaemon
- Pernaevit
- Pernipuron
- Plecyamin
- Poyamin
- Rebramin
- Redamina
- Redisol
- Rhodacryst
- Rubesol
- Rubramin
- Rubramin Pc
- Rubripca
- Rubrocitol
- Sytobex
- Vi-Twel
- Vibalt
- Vibisone
- Virubra
- Vita-Rubra
- Vitamin B12 BP
- Vitamin B12 Complex
- Vitamin B12 Preparation
- Vitamin B12b
- Vitamine B12
- Vitarubin
- Vitral
Cobione Brand Names Mixture
- Liver-Stomach Concentrate with Intrinsic Factor (Special Liver-Stomach Concentrate + Vitamin B 12 + Iron + Ascorbic Acid + Folic Acid)
Cobione Chemical_Formula
C63H88CoN14O14P
Cobione RX_link
http://www.rxlist.com/cgi/generic2/hminfr.htm
Cobione fda sheet
Cobione msds (material safety sheet)
Cobione Synthesis Reference
No information avaliable
Cobione Molecular Weight
1355.37 g/mol
Cobione Melting Point
> 300 oC
Cobione H2O Solubility
1.25E+004 mg/L
Cobione State
Solid
Cobione LogP
3.57
Cobione Dosage Forms
Intra-nasal gel; Parenteral (oral)
Cobione Indication
For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.
Cobione Pharmacology
Vitamin B12 is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It isneeded for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia.
Cobione Absorption
Readily absorbed in the lower half of the ileum.
Cobione side effects and Toxicity
Anaphylactic reaction (skin rash, itching, wheezing)-after parenteral administration. ORL-MUS LD50 > 8000 mg/kg
Cobione Patient Information
Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration. A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.
Cobione Organisms Affected
Humans and other mammals
