Cycobemin
Brand names,
Cycobemin
Analogs
Cycobemin
Brand Names Mixture
- Liver-Stomach Concentrate with Intrinsic Factor (Special Liver-Stomach Concentrate + Vitamin B 12 + Iron + Ascorbic Acid + Folic Acid)
Cycobemin
Chemical_Formula
C63H88CoN14O14P
Cycobemin
RX_link
http://www.rxlist.com/cgi/generic2/hminfr.htm
Cycobemin
fda sheet
Cycobemin
msds (material safety sheet)
Cycobemin
Synthesis Reference
No information avaliable
Cycobemin
Molecular Weight
1355.37 g/mol
Cycobemin
Melting Point
> 300 oC
Cycobemin
H2O Solubility
1.25E+004 mg/L
Cycobemin
State
Solid
Cycobemin
LogP
3.57
Cycobemin
Dosage Forms
Intra-nasal gel; Parenteral (oral)
Cycobemin
Indication
For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.
Cycobemin
Pharmacology
Vitamin B12 is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It isneeded for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia.
Cycobemin
Absorption
Readily absorbed in the lower half of the ileum.
Cycobemin
side effects and Toxicity
Anaphylactic reaction (skin rash, itching, wheezing)-after parenteral administration. ORL-MUS LD50 > 8000 mg/kg
Cycobemin
Patient Information
Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration. A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.
Cycobemin
Organisms Affected
Humans and other mammals