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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C15H10Cl2N2O2
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RX_link
http://www.rxlist.com/cgi/generic/loraz.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Childress, Gluckman, J. Pharm. Sci. 53, 577 (1964)
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Molecular Weight
321.158 g/mol
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Melting Point
166-168oC
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H2O Solubility
0.08 mg/mL
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State
Solid
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LogP
2.959
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Dosage Forms
Tablet; Injection
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Indication
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms
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Pharmacology
Lorazepam, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia.
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Absorption
Readily absorbed with an absolute bioavailability of 90%.
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side effects and Toxicity
Somnolence, confusion, and coma, LD50=3178mg/kg (orally in mice).
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Patient Information
Lorazepam is a benzodiazepine used for the treatment of anxiety, anxiety with depression, and insomnia. Inform
your physician if you are pregnant or nursing. Lorazepam may cause dizziness and drowsiness; use caution while
driving or operating hazardous machinery. Do not take any other sedating drugs or drink alcohol while taking this
medication. Lorazepam may be habit forming. It is advisable that patients consult with their physician before
changing the dose. Withdrawal symptoms may occur after you stop taking it. This medication may be taken with or
without food.
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Organisms Affected
Humans and other mammals