(+/-)-Lorazepam
Brand names,
(+/-)-Lorazepam
Analogs
(+/-)-Lorazepam
Brand Names Mixture
(+/-)-Lorazepam
Chemical_Formula
C15H10Cl2N2O2
(+/-)-Lorazepam
RX_link
http://www.rxlist.com/cgi/generic/loraz.htm
(+/-)-Lorazepam
fda sheet
(+/-)-Lorazepam
msds (material safety sheet)
(+/-)-Lorazepam
Synthesis Reference
Childress, Gluckman, J. Pharm. Sci. 53, 577 (1964)
(+/-)-Lorazepam
Molecular Weight
321.158 g/mol
(+/-)-Lorazepam
Melting Point
166-168oC
(+/-)-Lorazepam
H2O Solubility
0.08 mg/mL
(+/-)-Lorazepam
State
Solid
(+/-)-Lorazepam
LogP
2.959
(+/-)-Lorazepam
Dosage Forms
Tablet; Injection
(+/-)-Lorazepam
Indication
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms
(+/-)-Lorazepam
Pharmacology
Lorazepam, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia.
(+/-)-Lorazepam
Absorption
Readily absorbed with an absolute bioavailability of 90%.
(+/-)-Lorazepam
side effects and Toxicity
Somnolence, confusion, and coma, LD50=3178mg/kg (orally in mice).
(+/-)-Lorazepam
Patient Information
Lorazepam is a benzodiazepine used for the treatment of anxiety, anxiety with depression, and insomnia. Inform
your physician if you are pregnant or nursing. Lorazepam may cause dizziness and drowsiness; use caution while
driving or operating hazardous machinery. Do not take any other sedating drugs or drink alcohol while taking this
medication. Lorazepam may be habit forming. It is advisable that patients consult with their physician before
changing the dose. Withdrawal symptoms may occur after you stop taking it. This medication may be taken with or
without food.
(+/-)-Lorazepam
Organisms Affected
Humans and other mammals