Rotahaler
Brand names,
Rotahaler
Analogs
Rotahaler
Brand Names Mixture
Rotahaler
Chemical_Formula
C13H21NO3
Rotahaler
RX_link
http://www.rxlist.com/cgi/generic/duoneb.htm
Rotahaler
fda sheet
Rotahaler
msds (material safety sheet)
Rotahaler
Synthesis Reference
Collin et al., J. Med. Chem. 3,644,353 (1968,1972)
Rotahaler
Molecular Weight
239.311 g/mol
Rotahaler
Melting Point
157-158oC
Rotahaler
H2O Solubility
3 mg/L
Rotahaler
State
Solid
Rotahaler
LogP
1.311
Rotahaler
Dosage Forms
Oral solution; Syrup; Tablet; Tablet (extended-release); Injection (intramuscular, intravenous)
Rotahaler
Indication
For relief and prevention of bronchospasm due to asthma, emphysema, and chronic bronchitis
Rotahaler
Pharmacology
Albuterol, a moderately selective beta(2)-receptor agonist similar in structure to terbutaline, is widely used as a bronchodilator to manage asthma and other chronic obstructive airway diseases. The R-isomer, levalbuterol, is responsible for bronchodilation while the S-isomer increases bronchial reactivity.
Rotahaler
Absorption
Systemic absorption is rapid following aerosol administration
Rotahaler
side effects and Toxicity
LD50=1100 mg/kg (orally in mice)
Rotahaler
Patient Information
Rotahaler
Organisms Affected
Humans and other mammals