Ritalin hydrochloride
Brand names,
Ritalin hydrochloride
Analogs
Ritalin hydrochloride
Brand Names Mixture
Ritalin hydrochloride
Chemical_Formula
C14H19NO2
Ritalin hydrochloride
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
Ritalin hydrochloride
fda sheet
Ritalin hydrochloride
msds (material safety sheet)
Ritalin hydrochloride
Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Ritalin hydrochloride
Molecular Weight
233.306 g/mol
Ritalin hydrochloride
Melting Point
224-226oC
Ritalin hydrochloride
H2O Solubility
1255mg/L
Ritalin hydrochloride
State
Solid
Ritalin hydrochloride
LogP
3.192
Ritalin hydrochloride
Dosage Forms
Tablets; Tablets (sustained release)
Ritalin hydrochloride
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Ritalin hydrochloride
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Ritalin hydrochloride
Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
Ritalin hydrochloride
side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Ritalin hydrochloride
Patient Information
Ritalin hydrochloride
Organisms Affected
Humans and other mammals