Focalin XR
Brand names,
Focalin XR
Analogs
Focalin XR
Brand Names Mixture
Focalin XR
Chemical_Formula
C14H19NO2
Focalin XR
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
Focalin XR
fda sheet
Focalin XR
msds (material safety sheet)
Focalin XR
Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Focalin XR
Molecular Weight
233.306 g/mol
Focalin XR
Melting Point
224-226oC
Focalin XR
H2O Solubility
1255mg/L
Focalin XR
State
Solid
Focalin XR
LogP
3.192
Focalin XR
Dosage Forms
Tablets; Tablets (sustained release)
Focalin XR
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Focalin XR
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Focalin XR
Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
Focalin XR
side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Focalin XR
Patient Information
Focalin XR
Organisms Affected
Humans and other mammals