Metilfenidat hydrochloride
Brand names,
Metilfenidat hydrochloride
Analogs
Metilfenidat hydrochloride
Brand Names Mixture
Metilfenidat hydrochloride
Chemical_Formula
C14H19NO2
Metilfenidat hydrochloride
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
Metilfenidat hydrochloride
fda sheet
Metilfenidat hydrochloride
msds (material safety sheet)
Metilfenidat hydrochloride
Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Metilfenidat hydrochloride
Molecular Weight
233.306 g/mol
Metilfenidat hydrochloride
Melting Point
224-226oC
Metilfenidat hydrochloride
H2O Solubility
1255mg/L
Metilfenidat hydrochloride
State
Solid
Metilfenidat hydrochloride
LogP
3.192
Metilfenidat hydrochloride
Dosage Forms
Tablets; Tablets (sustained release)
Metilfenidat hydrochloride
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Metilfenidat hydrochloride
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Metilfenidat hydrochloride
Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
Metilfenidat hydrochloride
side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Metilfenidat hydrochloride
Patient Information
Metilfenidat hydrochloride
Organisms Affected
Humans and other mammals