Metadate CD
Brand names,
Metadate CD
Analogs
Metadate CD
Brand Names Mixture
Metadate CD
Chemical_Formula
C14H19NO2
Metadate CD
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
Metadate CD
fda sheet
Metadate CD
msds (material safety sheet)
Metadate CD
Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Metadate CD
Molecular Weight
233.306 g/mol
Metadate CD
Melting Point
224-226oC
Metadate CD
H2O Solubility
1255mg/L
Metadate CD
State
Solid
Metadate CD
LogP
3.192
Metadate CD
Dosage Forms
Tablets; Tablets (sustained release)
Metadate CD
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Metadate CD
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Metadate CD
Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
Metadate CD
side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Metadate CD
Patient Information
Metadate CD
Organisms Affected
Humans and other mammals