Methypatch
Brand names,
Methypatch
Analogs
Methypatch
Brand Names Mixture
Methypatch
Chemical_Formula
C14H19NO2
Methypatch
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Methypatch
Molecular Weight
233.306 g/mol
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Melting Point
224-226oC
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H2O Solubility
1255mg/L
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State
Solid
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LogP
3.192
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Dosage Forms
Tablets; Tablets (sustained release)
Methypatch
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Methypatch
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
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Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
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side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Methypatch
Patient Information
Methypatch
Organisms Affected
Humans and other mammals