Methylphenidylacetate hydrochloride
Brand names,
Methylphenidylacetate hydrochloride
Analogs
Methylphenidylacetate hydrochloride
Brand Names Mixture
Methylphenidylacetate hydrochloride
Chemical_Formula
C14H19NO2
Methylphenidylacetate hydrochloride
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
Methylphenidylacetate hydrochloride
fda sheet
Methylphenidylacetate hydrochloride
msds (material safety sheet)
Methylphenidylacetate hydrochloride
Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Methylphenidylacetate hydrochloride
Molecular Weight
233.306 g/mol
Methylphenidylacetate hydrochloride
Melting Point
224-226oC
Methylphenidylacetate hydrochloride
H2O Solubility
1255mg/L
Methylphenidylacetate hydrochloride
State
Solid
Methylphenidylacetate hydrochloride
LogP
3.192
Methylphenidylacetate hydrochloride
Dosage Forms
Tablets; Tablets (sustained release)
Methylphenidylacetate hydrochloride
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Methylphenidylacetate hydrochloride
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Methylphenidylacetate hydrochloride
Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
Methylphenidylacetate hydrochloride
side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Methylphenidylacetate hydrochloride
Patient Information
Methylphenidylacetate hydrochloride
Organisms Affected
Humans and other mammals