Methyl phenidyl acetate
Brand names,
Methyl phenidyl acetate
Analogs
Methyl phenidyl acetate
Brand Names Mixture
Methyl phenidyl acetate
Chemical_Formula
C14H19NO2
Methyl phenidyl acetate
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
Methyl phenidyl acetate
fda sheet
Methyl phenidyl acetate
msds (material safety sheet)
Methyl phenidyl acetate
Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Methyl phenidyl acetate
Molecular Weight
233.306 g/mol
Methyl phenidyl acetate
Melting Point
224-226oC
Methyl phenidyl acetate
H2O Solubility
1255mg/L
Methyl phenidyl acetate
State
Solid
Methyl phenidyl acetate
LogP
3.192
Methyl phenidyl acetate
Dosage Forms
Tablets; Tablets (sustained release)
Methyl phenidyl acetate
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Methyl phenidyl acetate
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Methyl phenidyl acetate
Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
Methyl phenidyl acetate
side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Methyl phenidyl acetate
Patient Information
Methyl phenidyl acetate
Organisms Affected
Humans and other mammals